tert-Butyl 2-bromo-2-methylpropionate → HCID 59180319, compound

HRID 416093Notes

Reaction equation

HRID 416093 reaction equation
[Cl:1][C:2]1[C:7]([Cl:8])=[C:6]([OH:9])[CH:5]=[CH:4][C:3]=1[CH2:10][CH2:11][C:12]([C:14]1[S:15][C:16]([C:19]2[CH:24]=[CH:23][C:22]([O:25][C:26]([F:29])([F:28])[F:27])=[CH:21][CH:20]=2)=[CH:17][CH:18]=1)=[O:13].Br[C:31]([CH3:40])([CH3:39])[C:32]([O:34][C:35]([CH3:38])([CH3:37])[CH3:36])=[O:33]>>[Cl:8][C:7]1[C:2]([Cl:1])=[C:3]([CH2:10][CH2:11][C:12](=[O:13])[C:14]2[S:15][C:16]([C:19]3[CH:24]=[CH:23][C:22]([O:25][C:26]([F:28])([F:29])[F:27])=[CH:21][CH:20]=3)=[CH:17][CH:18]=2)[CH:4]=[CH:5][C:6]=1[O:9][C:31]([CH3:40])([CH3:39])[C:32]([O:34][C:35]([CH3:38])([CH3:37])[CH3:36])=[O:33]

Participants

3

Reactant 2

HCID 90290tert-Butyl 2-bromo-2-methylpropionateHCID 59180359HCID 59180359, compound

Product 1

HCID 59180319HCID 59180319, compound

Procedure

Tert-butyl 2-(2,3-dichloro-4-(3-oxo-3-(5-(4-(trifluoromethoxy)phenyl)thien-2-yl)propyl)-phenoxy)-2-methylpropanoate is prepared from 3-(2,3-dichloro-4-hydroxyphenyl)-1-(5-(4-(trifluoromethoxy)phenyl)thien-2-yl)propan-1-one and tert-butyl bromoisobutyrate according to general procedure D.

Sources & evidence

ORD record
ord-d7ee986db8ad41a8bf8c5eff409092a6
Source dataset
uspto-grants-2012_01
Patent number
US08088819B2

Reaction notes

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