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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 416101Generated: October 27, 2026

Potassium Carbonate → Tert-butyl 2-(4-(3-(5-(4-bromophenyl)thien-2-yl)-3-oxopropyl)-2,3-dichlorophenoxy)-2-methylpropanoate

https://huagongshe.com/reaction/416101

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPotassium CarbonateHCID 11430—
Reactanttert-Butyl 2-bromo-2-methylpropionateHCID 90290—
Reactant1-(5-(4-Bromophenyl)thien-2-yl)-3-(2,3-dichloro-4-hydroxyphenyl)propan-1-oneHCID 59180330—
ProductTert-butyl 2-(4-(3-(5-(4-bromophenyl)thien-2-yl)-3-oxopropyl)-2,3-dichlorophenoxy)-2-methylpropanoateHCID 25061023—

Reaction Steps

Tert-butyl 2-(4-(3-(5-(4-bromophenyl)thien-2-yl)-3-oxopropyl)-2,3-dichlorophenoxy)-2-methylpropanoate is prepared from 1-(5-(4-bromophenyl)thien-2-yl)-3-(2,3-dichloro-4-hydroxyphenyl)propan-1-one according to general procedure D, using 4 equivalents of tert-butyl bromoisobutyrate and 5 equivalents of potassium carbonate.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08088819B2
Source datasetuspto-grants-2012_01
ORD IDord-f53665848c7a4b42bd3a43a7da6025ef
Source noteuspto-grants-2012_01