tert-Butyl 2-bromobutanoate → HCID 59180353, compound

HRID 416108Notes

Reaction equation

HRID 416108 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][C:10]([C:12]2[S:13][C:14]([C:17]3[CH:22]=[CH:21][C:20]([C:23]([F:26])([F:25])[F:24])=[CH:19][CH:18]=3)=[CH:15][CH:16]=2)=[O:11])=[CH:4][CH:3]=1.Br[CH:28]([CH2:36][CH3:37])[C:29]([O:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:30]>>[O:11]=[C:10]([C:12]1[S:13][C:14]([C:17]2[CH:22]=[CH:21][C:20]([C:23]([F:26])([F:24])[F:25])=[CH:19][CH:18]=2)=[CH:15][CH:16]=1)[CH2:9][CH2:8][C:5]1[CH:6]=[CH:7][C:2]([O:1][CH:28]([CH2:36][CH3:37])[C:29]([O:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:30])=[CH:3][CH:4]=1

Participants

3

Reactant 2

HCID 13124118tert-Butyl 2-bromobutanoateHCID 59180333HCID 59180333, compound

Product 1

HCID 59180353HCID 59180353, compound

Procedure

Tert-butyl 2-(4-(3-oxo-3-(5-(4-(trifluoromethyl)phenyl)thien-2-yl)propyl)-phenoxy)butanoate is prepared from 3-(4-hydroxyphenyl)-1-(5-(4-(trifluoromethyl)-phenyl)thien-2-yl)propan-1-one and tert-butyl 2-bromobutanoate according to general procedure D.

Sources & evidence

ORD record
ord-88160b5a21ad4c47ad43a4313a0f5131
Source dataset
uspto-grants-2012_01
Patent number
US08088819B2

Reaction notes

Loading…