Propanoic acid, 2-bromo-2-methyl-, ethyl ester → HCID 66624023, compound

HRID 416115Notes

Reaction equation

HRID 416115 reaction equation
[Cl:1][C:2]1[C:7]([Cl:8])=[C:6]([OH:9])[CH:5]=[CH:4][C:3]=1[CH2:10][CH2:11][C:12]([C:14]1[S:15][C:16]([C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([C:25]([F:28])([F:27])[F:26])[CH:20]=2)=[CH:17][CH:18]=1)=[O:13].Br[C:30]([CH3:37])([CH3:36])[C:31]([O:33][CH2:34][CH3:35])=[O:32]>>[Cl:8][C:7]1[C:2]([Cl:1])=[C:3]([CH2:10][CH2:11][C:12](=[O:13])[C:14]2[S:15][C:16]([C:19]3[CH:24]=[CH:23][CH:22]=[C:21]([C:25]([F:27])([F:28])[F:26])[CH:20]=3)=[CH:17][CH:18]=2)[CH:4]=[CH:5][C:6]=1[O:9][C:30]([CH3:37])([CH3:36])[C:31]([O:33][CH2:34][CH3:35])=[O:32]

Participants

3

Reactant 2

HCID 11745Propanoic acid, 2-bromo-2-methyl-, ethyl esterHCID 59180307HCID 59180307, compound

Product 1

HCID 66624023HCID 66624023, compound

Procedure

Ethyl 2-(2,3-dichloro-4-(3-oxo-3-(5-(3-(trifluoromethyl)phenyl)thien-2-yl)propyl)-phenoxy)-2-methylpropanoate is prepared from 3-(2,3-dichloro-4-hydroxy-phenyl)-1-(5-(3-(trifluoromethyl)phenyl)thien-2-yl)propan-1-one and ethyl bromo-isobutyrate according to general procedure D.

Sources & evidence

ORD record
ord-7c66aabb4b2840b0b94c514c5b6a8e81
Source dataset
uspto-grants-2012_01
Patent number
US08088819B2

Reaction notes

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