Sodium Hydroxide → HCID 59180305, compound

HRID 416116Notes

Reaction equation

[Cl:1][C:2]1[C:16]([Cl:17])=[C:15]([CH2:18][CH2:19][C:20](=[O:36])[C:21]2[S:22][C:23]([C:26]3[CH:31]=[CH:30][CH:29]=[C:28]([C:32]([F:35])([F:34])[F:33])[CH:27]=3)=[CH:24][CH:25]=2)[CH:14]=[CH:13][C:3]=1[O:4][C:5]([CH3:12])([CH3:11])[C:6]([O:8]CC)=[O:7].[OH-].[Na+]>>[Cl:1][C:2]1[C:16]([Cl:17])=[C:15]([CH2:18][CH2:19][C:20](=[O:36])[C:21]2[S:22][C:23]([C:26]3[CH:31]=[CH:30][CH:29]=[C:28]([C:32]([F:33])([F:34])[F:35])[CH:27]=3)=[CH:24][CH:25]=2)[CH:14]=[CH:13][C:3]=1[O:4][C:5]([CH3:11])([CH3:12])[C:6]([OH:8])=[O:7]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 66624023HCID 66624023, compound

Product 1

HCID 59180305HCID 59180305, compound

Procedure

2-(2,3-Dichloro-4-(3-oxo-3-(5-(3-(trifluoromethyl)phenyl)thien-2-yl)propyl)-phenoxy)-2-methylpropanoic acid is prepared from ethyl 2-(2,3-dichloro-4-(3-oxo-3-(5-(3-(trifluoromethyl)phenyl)thien-2-yl)propyl)phenoxy)-2-methylpropanoate according to general procedure F using 10 equivalents of 2N sodium hydroxide solution.

Sources & evidence

ORD record: ord-acc9d48ae89c4661891ab9e84830f8ad
Source dataset: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08088819B2

Reaction notes

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