反应详情

A solution of 5 g of (3R,3aS,6R,6aR)-hexahydro-furo[3,2-b]furan-3,6-diol in 50 ml of pyridine is stirred for 16 h with 7.8 g of toluenesulfonylchloride. From the mixture obtained solvent is distilled off and the distillation residue obtained is dissolved in EtAc and extracted with 1N HCl, saturated aqueous NaHCO3-solution and H2O. The organic layer obtained is dried, solvent is evaporated and the evaporation residue is subjected to chromatography. Toluene-4-sulfonic acid (3R, 3aS,6R,6aR)-6-hydroxy-hexahydro-furo[3,2-b]furan-3-yl ester is obtained.

1. customFrom the mixture obtained solvent
2. distillationis distilled off
3. customthe distillation residue obtained
4. dissolutionis dissolved in EtAc
5. extractionextracted with 1N HCl, saturated aqueous NaHCO3-solution and H2O
6. customThe organic layer obtained
7. customis dried
8. customsolvent is evaporated