反应详情

A solution of 32 (1.25 g, 7.9 mmol) and morpholine (2.20 mL, 25.2 mmol) in EtOH (22 mL) was refluxed for 12 h and then evaporated to dryness. The residue was dissolved in EtOAc (200 mL), washed with saturated NaHCO3 (50 mL×2) and brine (50 mL), dried over Na2SO4, filtered and evaporated to afford the title compound 33a (1.66 g, quantitative yield) as a pale yellow solid.

1. customevaporated to dryness
2. dissolutionThe residue was dissolved in EtOAc (200 mL)
3. washwashed with saturated NaHCO3 (50 mL×2) and brine (50 mL)
4. dry with materialdried over Na2SO4
5. filtrationfiltered
6. customevaporated