反应详情

温度

90 °C

A 50 mL flask equipped with a reflux condenser was charged with morpholine (2.93 mL, 33.5 mmol) and 3,6-dichloropyridazine (5.00 g, 33.5 mmol). The mixture was heated at 90° C. for 6 h, the resultant solid was partitioned between EtOAc, water and saturated NH4Cl. Organic layer was separated, dried over anhydrous Na2SO4, filtered, and evaporated to afford the title compound 64 (5.3 g, 26.5 mmol, 79% yield).

1. customA 50 mL flask equipped with a reflux condenser
2. customthe resultant solid was partitioned between EtOAc, water and saturated NH4Cl
3. customOrganic layer was separated
4. dry with materialdried over anhydrous Na2SO4
5. filtrationfiltered
6. customevaporated