HCID 58930642, compound → HCID 58930605, compound

HRID 416237Notes

Reaction equation

HRID 416237 reaction equation
[CH3:1][O:2][C:3](=[O:23])[C:4]1[CH:9]=[CH:8][C:7]([CH2:10][C:11](=O)[NH:12][C:13]2[CH:18]=[C:17]([F:19])[C:16]([Cl:20])=[CH:15][C:14]=2[NH2:21])=[CH:6][CH:5]=1>CC(O)=O>[CH3:1][O:2][C:3](=[O:23])[C:4]1[CH:9]=[CH:8][C:7]([CH2:10][C:11]2[NH:12][C:13]3[CH:18]=[C:17]([F:19])[C:16]([Cl:20])=[CH:15][C:14]=3[N:21]=2)=[CH:6][CH:5]=1

Participants

3

Reactant 1

HCID 58930642HCID 58930642, compound

Product 1

HCID 58930605HCID 58930605, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Compound 72 (333 mg, 0.99 mmol) was dissolved in AcOH (10 ml) and the solution was refluxed, for 24 h. AcOH was evaporated and the residue was dissolved in AcOEt, washed with aqueous NH4Cl, NaHCO3 and brine, and dried over MgSO4. Evaporation of EtOAc provided the title compound 73 as a brownish powder (297 mg, 95%).

Workup

  1. temperaturethe solution was refluxed, for 24 h
  2. customAcOH was evaporated
  3. dissolutionthe residue was dissolved in AcOEt
  4. washwashed with aqueous NH4Cl, NaHCO3 and brine
  5. dry with materialdried over MgSO4
  6. customEvaporation of EtOAc

Sources & evidence

ORD record
ord-ebe0f98ff1ee4c069713f9b0de928256
Source dataset
uspto-grants-2012_01
Patent number
US08088805B2

Reaction notes

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