(E)-3-(Dimethylamino)-1-(pyrazin-2-YL)prop-2-EN-1-one → 4-((4-(2-(Tert-butoxycarbonylamino)-4-methylthiazol-5-yl)-pyrimidin-2-ylamino)methyl)benzoic acid

Participants

Role	Name	HCID	Charge
Reactant	(E)-3-(Dimethylamino)-1-(pyrazin-2-YL)prop-2-EN-1-one	HCID 5825354	—
Reactant	(E)-1-[2-(Boc-Amino-)-4-methylthiazol-5-yl]-3-(dimethylamino)prop-2-en-1-one	HCID 58930506	—
Reactant	4-[(4-Pyrazin-2-yl-pyrimidin-2-ylamino)-methyl]-benzoic acid	HCID 66622167	—
Product	4-((4-(2-(Tert-butoxycarbonylamino)-4-methylthiazol-5-yl)-pyrimidin-2-ylamino)methyl)benzoic acid	HCID 58930474	18%

Reaction Steps

Following the procedure described for the synthesis of the acid 25a (scheme 6, step 3) but substituting enamino ketone 23a for the enamino ketone 338, title compound was obtained in 18% yield and was used for the next steps without further purification. MS (m/z): 441.50 (calc) 442.3 (MH+) (found).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08088805B2
Source dataset	uspto-grants-2012_01
ORD ID	ord-aeeadea4a66a45d79c56970b509663a4
Source note	uspto-grants-2012_01