4-(4-(Pyridin-3-yl)pyrimidin-2-ylamino)benzoic acid → 4-(4-(Pyridin-3-yl)pyrimidin-2-ylamino)-N-(2-aminophenyl)benzamide

HRID 416284Notes

Reaction equation

HRID 416284 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9](=[O:30])[C:10]1[CH:15]=[CH:14][C:13](CNC2N=C(C3C=NC=CN=3)C=CN=2)=[CH:12][CH:11]=1.[N:31]1[CH:36]=[CH:35][CH:34]=[C:33]([C:37]2[CH:42]=[CH:41][N:40]=[C:39]([NH:43]C3C=CC(C(O)=O)=CC=3)[N:38]=2)[CH:32]=1>>[N:31]1[CH:36]=[CH:35][CH:34]=[C:33]([C:37]2[CH:42]=[CH:41][N:40]=[C:39]([NH:43][C:13]3[CH:12]=[CH:11][C:10]([C:9]([NH:8][C:3]4[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=4[NH2:1])=[O:30])=[CH:15][CH:14]=3)[N:38]=2)[CH:32]=1

Participants

3

Reactant 2

HCID 143469704-(4-(Pyridin-3-yl)pyrimidin-2-ylamino)benzoic acidHCID 44570891N-(2-aminophenyl)-4-((4-(pyrazin-2-yl)pyrimidin-2-ylamino)methyl)benzamide

Product 1

HCID 445713334-(4-(Pyridin-3-yl)pyrimidin-2-ylamino)-N-(2-aminophenyl)benzamide

Procedure

Title compound was obtained in 54% yield according to the procedure described for the synthesis of compound 26a (scheme 6, step 4) replacing acid 25a by the acid 343. Characterization of the title compound is provided in the Table 12.

Sources & evidence

ORD record
ord-192d742e1ed242a5bb2c2566d7bb63df
Source dataset
uspto-grants-2012_01
Patent number
US08088805B2

Reaction notes

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