HRID416285

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CN(C)CCOc1ccc(-c2ccnc(NCc3ccc(C(=O)Nc4ccccc4N)cc3)n2)cc1

HCID44570974

未命名化合物

结构：Nc1ccccc1NC(=O)c1ccc2nc(-c3ccc(OC(F)(F)F)cc3)sc2c1

HCID66622185

未命名化合物

结构：CC(C)(C)OC(=O)Nc1ccccc1NC(=O)c1ccc(C=C2SC(=O)NC2=O)cc1

HCID72466473

未命名化合物

PRODUCTS

生成物

结构：Nc1ccccc1NC(=O)c1ccc(C=C2SC(=O)NC2=O)cc1

HCID72466478

未命名化合物

收率 37%

PROCEDURE

实验过程

Following the procedure described for the synthesis of compound 117 (scheme 28) but substituting the amide 116 by the amide 348, title compound was obtained in 37% yield. 1H NMR: (400 MHz, DMSO-d6, δ (Ppm): 9.72 (s, 1H), 8.06 (d, j=8.2 Hz, 2H), 7.79 (s, 1H), 7.69 (d, J=8.4, 2H), 7.14 (d (dd) J=7.8, 1H), 6.95 (d (dd), J=1.6 Hz, J=9.0, 1H), 6.75 (dd, J=1.2 Hz, J=8.0 Hz, 1H), 6.56 (t (dd), J=7.2 Hz 1H). LRMS: 339.4 (calcd.), 340.4 [MH]+ (found).