反应详情

To a solution of methyl isoquinoline-3-carboxylate (10 g, 53.42 mmol) in ethanol (100 mL) was added hydrazine (17.1 g). The reaction mixture was refluxed for 30 min and concentrated under high vacuum to remove hydrazine. The resulting residue was triturated with ethanol (20 mL) to give isoquinoline-3-carbohydrazide (8.6 g, 86%). LRMS (M+H+) m/z 188.1.

1. temperatureThe reaction mixture was refluxed for 30 min
2. concentrationconcentrated under high vacuum
3. customto remove hydrazine
4. customThe resulting residue was triturated with ethanol (20 mL)