6-(4-Chloro-phenyl)-5-cyclopropylmethoxy-3-trifluoromethyl-pyrazine-2-carboxylic acid (2-cyclopropyl-2-hydroxy-propyl)-amide → (3-Chloro-phenyl)-5-cyclopropylmethoxy-3-trifluoromethyl-pyrazine-2-carboxylic acid (2-cyclopropyl-2-hydroxy-propyl)-amide

HRID 416477Notes

Reaction equation

HRID 416477 reaction equation
[CH:1]1([C:4]([OH:32])([CH3:31])[CH2:5][NH:6][C:7]([C:9]2[C:14]([C:15]([F:18])([F:17])[F:16])=[N:13][C:12]([O:19][CH2:20][CH:21]3[CH2:23][CH2:22]3)=[C:11](C3C=CC(Cl)=CC=3)[N:10]=2)=[O:8])[CH2:3][CH2:2]1.C1(C(O)(C)CNC(C2C(C(F)(F)F)=NC(Br)=C([C:52]3[CH:57]=[CH:56][CH:55]=[C:54]([Cl:58])[CH:53]=3)N=2)=O)CC1>>[CH:1]1([C:4]([OH:32])([CH3:31])[CH2:5][NH:6][C:7]([C:9]2[C:14]([C:15]([F:18])([F:16])[F:17])=[N:13][C:12]([O:19][CH2:20][CH:21]3[CH2:23][CH2:22]3)=[C:11]([C:52]3[CH:57]=[CH:56][CH:55]=[C:54]([Cl:58])[CH:53]=3)[N:10]=2)=[O:8])[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 444634646-(4-Chloro-phenyl)-5-cyclopropylmethoxy-3-trifluoromethyl-pyrazine-2-carboxylic acid (2-cyclopropyl-2-hydroxy-propyl)-amideHCID 866347075-Bromo-6-(3-chloro-phenyl)-3-trifluoromethyl-pyrazine-2-carboxylic acid (2-cyclopropyl-2-hydroxy-propyl)-amide

Product 1

HCID 44463465(3-Chloro-phenyl)-5-cyclopropylmethoxy-3-trifluoromethyl-pyrazine-2-carboxylic acid (2-cyclopropyl-2-hydroxy-propyl)-amide

Procedure

In analogy to example 3 (6-(4-chloro-phenyl)-5-cyclopropylmethoxy-3-trifluoromethyl-pyrazine-2-carboxylic acid (2-cyclopropyl-2-hydroxy-propyl)-amide) the title compound was prepared by substituting 5-bromo-6-(4-chloro-phenyl)-3-trifluoromethyl-pyrazine-2-carboxylic acid (2-cyclopropyl-2-hydroxy-propyl)-amide with 5-bromo-6-(3-chloro-phenyl)-3-trifluoromethyl-pyrazine-2-carboxylic acid (2-cyclopropyl-2-hydroxy-propyl)-amide.

Sources & evidence

ORD record
ord-7a7db7c8173144028cf56f8e875a1739
Source dataset
uspto-grants-2012_01
Patent number
US08088920B2

Reaction notes

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