6-(3-Chloro-phenyl)-5-(2,2,2-trifluoro-ethoxy)-3-trifluoromethyl-pyrazine-2-carboxylic acid (2-cyclopropyl-2-hydroxy-propyl)-amide → 6-(4-Methanesulfonylamino-phenyl)-5-(2,2,2-trifluoro-ethoxy)-3-trifluoromethyl-pyrazine-2-carboxylic acid (2-cyclopropyl-2-hydroxy-propyl)-amide

HRID 416483Notes

Reaction equation

HRID 416483 reaction equation
[CH:1]1([C:4]([OH:33])([CH3:32])[CH2:5][NH:6][C:7]([C:9]2[C:14]([C:15]([F:18])([F:17])[F:16])=[N:13][C:12]([O:19][CH2:20][C:21]([F:24])([F:23])[F:22])=[C:11]([C:25]3[CH:30]=[CH:29][CH:28]=[C:27](Cl)[CH:26]=3)[N:10]=2)=[O:8])[CH2:3][CH2:2]1.NC1C(C2C=CC([NH:52][S:53]([CH3:56])(=[O:55])=[O:54])=CC=2)=NC(Br)=C(C(F)(F)F)N=1>>[CH:1]1([C:4]([OH:33])([CH3:32])[CH2:5][NH:6][C:7]([C:9]2[C:14]([C:15]([F:18])([F:17])[F:16])=[N:13][C:12]([O:19][CH2:20][C:21]([F:24])([F:23])[F:22])=[C:11]([C:25]3[CH:30]=[CH:29][C:28]([NH:52][S:53]([CH3:56])(=[O:55])=[O:54])=[CH:27][CH:26]=3)[N:10]=2)=[O:8])[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 444634626-(3-Chloro-phenyl)-5-(2,2,2-trifluoro-ethoxy)-3-trifluoromethyl-pyrazine-2-carboxylic acid (2-cyclopropyl-2-hydroxy-propyl)-amideHCID 86634709N-[4-(3-amino-6-bromo-5-trifluoromethyl-pyrazin-2-yl)-phenyl]-methanesulfonamide

Product 1

HCID 444629456-(4-Methanesulfonylamino-phenyl)-5-(2,2,2-trifluoro-ethoxy)-3-trifluoromethyl-pyrazine-2-carboxylic acid (2-cyclopropyl-2-hydroxy-propyl)-amide

Procedure

This compound was prepared in analogy to example 5 (6-(3-chloro-phenyl)-5-(2,2,2-trifluoro-ethoxy)-3-trifluoromethyl-pyrazine-2-carboxylic acid (2-cyclopropyl-2-hydroxy-propyl)-amide) by substituting 5-bromo-3-(3-chloro-phenyl)-6-trifluoromethyl-pyrazin-2-ylamine by N-[4-(3-amino-6-bromo-5-trifluoromethyl-pyrazin-2-yl)-phenyl]-methanesulfonamide.

Sources & evidence

ORD record
ord-a15e0683aae4465590aaac89ebbab310
Source dataset
uspto-grants-2012_01
Patent number
US08088920B2

Reaction notes

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