HRID416483

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(O)(CNC(=O)c1nc(-c2cccc(Cl)c2)c(OCC(F)(F)F)nc1C(F)(F)F)C1CC1

HCID44463462

未命名化合物

结构：CS(=O)(=O)Nc1ccc(-c2nc(Br)c(C(F)(F)F)nc2N)cc1

HCID86634709

未命名化合物

PRODUCTS

生成物

结构：CC(O)(CNC(=O)c1nc(-c2ccc(NS(C)(=O)=O)cc2)c(OCC(F)(F)F)nc1C(F)(F)F)C1CC1

HCID44462945

未命名化合物

PROCEDURE

实验过程

This compound was prepared in analogy to example 5 (6-(3-chloro-phenyl)-5-(2,2,2-trifluoro-ethoxy)-3-trifluoromethyl-pyrazine-2-carboxylic acid (2-cyclopropyl-2-hydroxy-propyl)-amide) by substituting 5-bromo-3-(3-chloro-phenyl)-6-trifluoromethyl-pyrazin-2-ylamine by N-[4-(3-amino-6-bromo-5-trifluoromethyl-pyrazin-2-yl)-phenyl]-methanesulfonamide.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a15e0683aae4465590aaac89ebbab310
来源数据集: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08088920B2
来源说明: uspto-grants-2012_01

反应 SMILES

[CH:1]1([C:4]([OH:33])([CH3:32])[CH2:5][NH:6][C:7]([C:9]2[C:14]([C:15]([F:18])([F:17])[F:16])=[N:13][C:12]([O:19][CH2:20][C:21]([F:24])([F:23])[F:22])=[C:11]([C:25]3[CH:30]=[CH:29][CH:28]=[C:27](Cl)[CH:26]=3)[N:10]=2)=[O:8])[CH2:3][CH2:2]1.NC1C(C2C=CC([NH:52][S:53]([CH3:56])(=[O:55])=[O:54])=CC=2)=NC(Br)=C(C(F)(F)F)N=1>>[CH:1]1([C:4]([OH:33])([CH3:32])[CH2:5][NH:6][C:7]([C:9]2[C:14]([C:15]([F:18])([F:17])[F:16])=[N:13][C:12]([O:19][CH2:20][C:21]([F:24])([F:23])[F:22])=[C:11]([C:25]3[CH:30]=[CH:29][C:28]([NH:52][S:53]([CH3:56])(=[O:55])=[O:54])=[CH:27][CH:26]=3)[N:10]=2)=[O:8])[CH2:3][CH2:2]1