HRID416484

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：O=C(N[C@@H]1CCCC[C@H]1O)c1nc(-c2cccc(Cl)c2)c(OCC2CC2)nc1C(F)(F)F

HCID44463719

未命名化合物

结构：CS(=O)(=O)Nc1ccc(-c2nc(Br)c(C(F)(F)F)nc2N)cc1

HCID86634709

未命名化合物

PRODUCTS

生成物

结构：CS(=O)(=O)Nc1ccc(-c2nc(C(=O)N[C@@H]3CCCC[C@H]3O)c(C(F)(F)F)nc2OCC2CC2)cc1

HCID44462944

未命名化合物

PROCEDURE

实验过程

In analogy to example 6 (6-(3-chloro-phenyl)-5-cyclopropylmethoxy-3-trifluoromethyl-pyrazine-2-carboxylic acid ((1R,2R)-2-hydroxy-cyclohexyl)-amide) the title compound was prepared by substituting 5-bromo-3-(3-chloro-phenyl)-6-trifluoromethyl-pyrazin-2-ylamine with N-[4-(3-amino-6-bromo-5-trifluoromethyl-pyrazin-2-yl)-phenyl]-methanesulfonamide.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d0dd4acf98ac4e9294d1a2751695605c
来源数据集: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08088920B2
来源说明: uspto-grants-2012_01

反应 SMILES

[OH:1][C@@H:2]1[CH2:7][CH2:6][CH2:5][CH2:4][C@H:3]1[NH:8][C:9]([C:11]1[C:16]([C:17]([F:20])([F:19])[F:18])=[N:15][C:14]([O:21][CH2:22][CH:23]2[CH2:25][CH2:24]2)=[C:13]([C:26]2[CH:31]=[CH:30][CH:29]=[C:28](Cl)[CH:27]=2)[N:12]=1)=[O:10].NC1C(C2C=CC([NH:51][S:52]([CH3:55])(=[O:54])=[O:53])=CC=2)=NC(Br)=C(C(F)(F)F)N=1>>[OH:1][C@@H:2]1[CH2:7][CH2:6][CH2:5][CH2:4][C@H:3]1[NH:8][C:9]([C:11]1[C:16]([C:17]([F:20])([F:19])[F:18])=[N:15][C:14]([O:21][CH2:22][CH:23]2[CH2:25][CH2:24]2)=[C:13]([C:26]2[CH:31]=[CH:30][C:29]([NH:51][S:52]([CH3:55])(=[O:54])=[O:53])=[CH:28][CH:27]=2)[N:12]=1)=[O:10]