反应详情

300 mg (0.76 mmol) of pure 5-chloro-thiophene-2-carboxylic acid [2-(1-isopropyl-piperidin-4-ylsulfamoyl)-ethyl]-amide were dissolved in 1.5 ml acetone. 88.4 mg (1 equiv.) fumaric acid, dissolved in a mixture of 3 ml acetone and 0.1 ml water, were added dropwise. After 48 h the formed precipitate was filtered off and washed with 3 ml cold acetone. The filter residue was dried at 35° C. under vacuo to give crystalline 5-chloro-thiophene-2-carboxylic acid [2-(1-isopropyl-piperidin-4-ylsulfamoyl)-ethyl]-amide fumarate.

1. additionwere added dropwise
2. filtrationAfter 48 h the formed precipitate was filtered off
3. washwashed with 3 ml cold acetone
4. customThe filter residue was dried at 35° C. under vacuo