2-Phthalimidoethanesulfonyl chloride → 2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-ethanesulfonic acid (4-benzyl-piperazin-1-yl)-amide

HRID 416502Notes

Reaction equation

HRID 416502 reaction equation
[CH2:1]([N:8]1[CH2:13][CH2:12][N:11]([NH2:14])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[O:15]=[C:16]1[C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[C:18](=[O:25])[N:17]1[CH2:26][CH2:27][S:28](Cl)(=[O:30])=[O:29]>>[CH2:1]([N:8]1[CH2:9][CH2:10][N:11]([NH:14][S:28]([CH2:27][CH2:26][N:17]2[C:16](=[O:15])[C:24]3[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=3)[C:18]2=[O:25])(=[O:29])=[O:30])[CH2:12][CH2:13]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 3087392-Phthalimidoethanesulfonyl chlorideHCID 121984534-Benzylpiperazin-1-amine

Product 1

HCID 666248472-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-ethanesulfonic acid (4-benzyl-piperazin-1-yl)-amide

Procedure

2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-ethanesulfonic acid (4-benzyl-piperazin-1-yl)-amide was prepared by an analogous procedure as described for example 1 i) starting from 140 mg (0.73 mmol) 4-benzyl-piperazin-1-ylamine and 200 mg (1 equiv.) 2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethanesulfonyl chloride. The product was obtained in crude form as a light yellow foam.

Workup

  1. customThe product was obtained in crude form as a light yellow foam

Sources & evidence

ORD record
ord-eb8b2c9e31f34f9aa5d7f862ed206118
Source dataset
uspto-grants-2012_01
Patent number
US08088925B2

Reaction notes

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