5-Chloro-2-thiophenecarboxylic acid → HCID 66625064, compound

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Reaction Steps

5-Chloro-thiophene-2-carboxylic acid [2-(4-benzyl-piperazin-1-ylsulfamoyl)-ethyl]-amide was prepared by an analogous procedure as described in example 5 iii) starting from 100 mg (1 equiv.) 5-chloro-thiophene-2-carboxylic acid and 183 mg (0.61 mmol) 2-amino-ethanesulfonic acid (4-benzyl-piperazin-1-yl)-amide. Final purification by preparative RP-HPLC (CH3CN/H2O gradient+0.1% TFA) gave pure 5-chloro-thiophene-2-carboxylic acid [2-(4-benzyl-piperazin-1-ylsulfamoyl)-ethyl]-amide. The title compound was obtained as its trifluoroacetate in form of a colorless amorphous material. Yield: 41 mg

Provenance & Evidence