3-(Chloromethyl)pyridine hydrochloride → HCID 66624915, compound

Participants

Reaction Steps

5-Chloro-thiophene-2-carboxylic acid {2-[(1-isopropyl-piperidin-4-yl)-pyridin-3-ylmethyl-sulfamoyl]-ethyl}-amide was prepared by an analogous procedure as described in example 15 starting from 83 mg (1 equiv.) 3-chloromethyl-pyridine hydrochloride and 200 mg (0.50 mmol) 5-chloro-thiophene-2-carboxylic acid [2-(1-isopropyl-piperidin-4-ylsulfamoyl)-ethyl]-amide (reaction temperature: 60° C.). Final purification by preparative RP-HPLC (CH3CN/H2O gradient+0.1% TFA) gave pure 5-chloro-thiophene-2-carboxylic acid {2-[(1-isopropyl-piperidin-4-yl)-pyridin-3-ylmethyl-sulfamoyl]-ethyl}-amide. The title compound was obtained as its trifluoroacetate in form of a light yellow amorphous material.

Provenance & Evidence