2-Phthalimidoethanesulfonyl chloride → HCID 66625058, compound

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2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-ethanesulfonic acid (1-isopropyl-piperidin-4-yl)-thiazol-2-ylmethyl-amide was prepared by an analogous procedure as described for example 1 i) starting from 217 mg (0.91 mmol) (1-isopropyl-piperidin-4-yl)-thiazol-2-ylmethyl-amine and 250 mg (1 equiv.) 2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethanesulfonyl chloride. Purification by flash chromatography on silica gel (eluent: CH2Cl2/MeOH) gave pure 2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethanesulfonic acid (1-isopropyl-piperidin-4-yl)-thiazol-2-ylmethyl-amide as a light yellow foam. Yield: 178 mg MS (ES+): m/e=477.

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