5-Chloro-2-thiophenecarboxylic acid → HCID 66625006, compound

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Reaction Steps

5-Chloro-thiophene-2-carboxylic acid [(S)-1-hydroxymethyl-2-(1-isopropyl-piperidin-4-ylsulfamoyl)-ethyl]-amide was prepared by an analogous procedure as described in example 26 viii) starting from 28 mg (1.1 equiv.) 5-chloro-thiophene-2-carboxylic acid and 44 mg (0.16 mmol) (S)-2-amino-3-hydroxy-propane-1-sulfonic acid (1-isopropyl-piperidin-4-yl)-amide. Final purification by preparative RP-HPLC (CH3CN/H2O gradient+0.1% TFA) gave pure 5-chloro-thiophene-2-carboxylic acid [(S)-1-hydroxymethyl-2-(1-isopropyl-piperidin-4-ylsulfamoyl)-ethyl]-amide. The title compound was obtained as its trifluoroacetate in form of a colorless amorphous material.

Provenance & Evidence