Phosgene → HCID 86621463, compound

HRID 416529Notes

Reaction equation

[CH:1]1[C:13]2[CH:12]([CH2:14][O:15][C:16]([NH:18][C:19]([CH3:26])([CH3:25])[CH2:20][S:21](O)(=[O:23])=[O:22])=[O:17])[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]=2[CH:4]=[CH:3][CH:2]=1.C(Cl)([Cl:29])=O>>[CH:1]1[C:13]2[CH:12]([CH2:14][O:15][C:16](=[O:17])[NH:18][C:19]([CH3:26])([CH3:25])[CH2:20][S:21]([Cl:29])(=[O:23])=[O:22])[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]=2[CH:4]=[CH:3][CH:2]=1

Participants

Reactant 2

HCID 6371Phosgene

HCID 86621464HCID 86621464, compound

Product 1

HCID 86621463HCID 86621463, compound

Procedure

(2-Chlorosulfonyl-1,1-dimethyl-ethyl)-carbamic acid 9H-fluoren-9-ylmethyl ester was prepared by an analogous procedure as described in example 26v) starting from 457 mg (1.2 mmol) 2-(9H-fluoren-9-ylmethoxycarbonylamino)-2-methyl-propane-1-sulfonic acid and 2.3 ml (3.6 equiv.) phosgene (20% in toluene). (2-Chlorosulfonyl-1,1-dimethyl-ethyl)-carbamic acid 9H-fluoren-9-ylmethyl ester was obtained in crude form as a colorless oil. Yield: 503 mg

Workup

custom(2-Chlorosulfonyl-1,1-dimethyl-ethyl)-carbamic acid 9H-fluoren-9-ylmethyl ester was prepared by an analogous procedure

Sources & evidence

ORD record: ord-bbc31ea1ec034b3691efebfc25752e02
Source dataset: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08088925B2

Reaction notes

Loading…