1-(Propan-2-yl)piperidin-4-amine → HCID 66625201, compound

HRID 416530Notes

Reaction equation

HRID 416530 reaction equation
[CH:1]1[C:13]2[CH:12]([CH2:14][O:15][C:16](=[O:26])[NH:17][C:18]([CH3:25])([CH3:24])[CH2:19][S:20](Cl)(=[O:22])=[O:21])[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]=2[CH:4]=[CH:3][CH:2]=1.[CH:27]([N:30]1[CH2:35][CH2:34][CH:33]([NH2:36])[CH2:32][CH2:31]1)([CH3:29])[CH3:28]>>[CH:1]1[C:13]2[CH:12]([CH2:14][O:15][C:16](=[O:26])[NH:17][C:18]([CH3:25])([CH3:24])[CH2:19][S:20](=[O:22])(=[O:21])[NH:36][CH:33]3[CH2:34][CH2:35][N:30]([CH:27]([CH3:29])[CH3:28])[CH2:31][CH2:32]3)[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]=2[CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 31633331-(Propan-2-yl)piperidin-4-amineHCID 86621463HCID 86621463, compound

Product 1

HCID 66625201HCID 66625201, compound

Procedure

[2-(1-Isopropyl-piperidin-4-ylsulfamoyl)-1,1-dimethyl-ethyl]-carbamic acid 9H-fluoren-9-ylmethyl ester was prepared by an analogous procedure as described in example 26 vi) starting from 479 mg (1.2 mmol) (2-chlorosulfonyl-1,1-dimethyl-ethyl)-carbamic acid 9H-fluoren-9-ylmethyl ester and 208 mg (1.2 equiv.) 1-isopropyl-piperidin-4-ylamine. The product was obtained in crude form as light yellow foam. Yield: 678 mg MS (ES+): m/e=500.

Workup

  1. customThe product was obtained in crude form as light yellow foam

Sources & evidence

ORD record
ord-b200cc1163be4571a8030ad58ad23708
Source dataset
uspto-grants-2012_01
Patent number
US08088925B2

Reaction notes

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