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HRID416532

反应详情

EQUATION

反应方程式

HRID 416532 的结构方程式

REACTANTS

反应物

2
反应SMILES：O=C(O)c1ccc(Cl)s1
HCID95048

2-Thiophenecarboxylic acid, 5-chloro-

C5H3ClO2S

反应SMILES：CC(C)N1CCC(NS(=O)(=O)CC(C)(C)N)CC1
HCID66624635

未命名化合物

PRODUCTS

产物

1
反应SMILES：CC(C)N1CCC(NS(=O)(=O)CC(C)(C)NC(=O)c2ccc(Cl)s2)CC1
HCID66624916

未命名化合物

PROCEDURE

实验过程

5-Chloro-thiophene-2-carboxylic acid [2-(1-isopropyl-piperidin-4-ylsulfamoyl)-1,1-dimethyl-ethyl]-amide was prepared by an analogous procedure as described in example 26 viii) starting from 195 mg (1 equiv.) 5-chloro-thiophene-2-carboxylic acid and 332 mg (1.2 mmol) 2-amino-2-methyl-propane-1-sulfonicacid (1-isopropyl-piperidin-4-yl)-amide. Final purification by preparative RP-HPLC (CH3CN/H2O gradient+0.1% TFA) gave pure 5-chloro-thiophene-2-carboxylic acid [2-(1-isopropyl-piperidin-4-ylsulfamoyl)-1,1-dimethyl-ethyl]-amide. The title compound was obtained as its trifluoroacetate in form of a colorless amorphous material.

WORKUP

后处理

  1. custom5-Chloro-thiophene-2-carboxylic acid [2-(1-isopropyl-piperidin-4-ylsulfamoyl)-1,1-dimethyl-ethyl]-amide was prepared by an analogous procedure
  2. customFinal purification by preparative RP-HPLC (CH3CN/H2O gradient+0.1% TFA)