Methanesulfonyl chloride → HCID 86621466, compound

HRID 416537Notes

Reaction equation

[CH2:1]([O:8][C:9](=[O:25])[CH2:10][CH:11]([OH:24])[CH2:12][NH:13][C:14]([O:16][CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=[O:15])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:26][S:27](Cl)(=[O:29])=[O:28]>>[CH2:1]([O:8][C:9](=[O:25])[CH2:10][CH:11]([O:24][S:27]([CH3:26])(=[O:29])=[O:28])[CH2:12][NH:13][C:14]([O:16][CH2:17][C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1)=[O:15])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 31297Methanesulfonyl chloride

HCID 66625251HCID 66625251, compound

Product 1

HCID 86621466HCID 86621466, compound

Procedure

4-Benzyloxycarbonylamino-3-methanesulfonyloxy-butyric acid benzyl ester was prepared by an analogous procedure as described in example 26i) starting from 6.7 g (19.6 mmol) 4-benzyloxycarbonylamino-3-hydroxy-butyric acid benzyl ester and 1.84 ml (1.2 equiv.) methanesulfonyl chloride. 4-Benzyloxycarbonylamino-3-methanesulfonyloxy-butyric acid benzyl ester was obtained in crude form as yellow oil. Yield: 8.5 g.

Workup

custom4-Benzyloxycarbonylamino-3-methanesulfonyloxy-butyric acid benzyl ester was prepared by an analogous procedure

Sources & evidence

ORD record: ord-f8bd88d43ea0485199eb196e1623d9c7
Source dataset: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08088925B2

Reaction notes

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