HCID 22266500, compound → HCID 22266463, compound

HRID 416582Notes

Reaction equation

HRID 416582 reaction equation
C(OC([NH:11][C:12]1[C:13](=[O:24])[N:14]([CH2:20][CH2:21][CH2:22][CH3:23])[C:15]([CH3:19])=[C:16]([CH3:18])[CH:17]=1)=O)C1C=CC=CC=1>CO.[Pd].O>[NH2:11][C:12]1[C:13](=[O:24])[N:14]([CH2:20][CH2:21][CH2:22][CH3:23])[C:15]([CH3:19])=[C:16]([CH3:18])[CH:17]=1

Participants

5

Reactant 1

HCID 22266500HCID 22266500, compound

Product 1

HCID 22266463HCID 22266463, compoundYield 97.8%

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 887MethanolSolventHCID 962WaterSolvent

Procedure

3-Benzyloxycarbonylamino-1-butyl-5,6-dimethyl-2-pyridone (5-017) (2.487 g) was dissolved in methanol (25 mL), and to the reaction mixture was added a suspension of 10% palladium on carbon (373 mg) in water (2.5 mL), and the reaction mixture was reacted in catalytic reduction under atmospheric pressure. After 4 h, the reaction mixture filtered off on Celite, washed with methanol, and evaporated under reduced pressure to give 3-amino-1-butyl-5,6-dimethyl-2-pyridone (5-004-02) (1.438 g, 97.8%, m.p. 94 to 97° C.) as a brown crystal.

Workup

  1. additionto the reaction mixture was added
  2. customthe reaction mixture was reacted in catalytic reduction under atmospheric pressure
  3. filtrationthe reaction mixture filtered off on Celite
  4. washwashed with methanol
  5. customevaporated under reduced pressure

Sources & evidence

ORD record
ord-b54a5ce45f4c483b95a14a71cea6f3a0
Source dataset
uspto-grants-2012_01
Patent number
US08088924B2

Reaction notes

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