HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Chloride → 4-(Thiazolo[4,5-c]pyridin-2-yl)benzenamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | 2-(4-Nitrophenyl)thiazolo[4,5-c]pyridine | HCID 21770648 | — |
| Catalyst | Iron | HCID 23925 | — |
| Solvent | Methanol--water (1/1) | HCID 22242641 | — |
| Product | 4-(Thiazolo[4,5-c]pyridin-2-yl)benzenamine | HCID 21770652 | 60.3% |
Reaction Steps
2-(4-nitrophenyl)thiazolo[4,5-c]pyridine (2.57 g, 0.01 mol), iron powder (2.8 g, 0.05 mmol) and NH4Cl (4.32 g, 0.08 mol) were refluxed in CH3OH/H2O (4:1, 200 mL) for 6 h. The mixture was filtered and the filtrate was evaporated in vacuo. The residue was washed with water (30 ml) to give 4-(thiazolo[4,5-c]pyridin-2-yl)benzenamine as a white solid (1.37 g, Yield: 60%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08088928B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-f192bbbcf3254c19995132564db99333 |
| Source note | uspto-grants-2012_01 |