HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 3-(5-Methyl-oxazolo[4,5-b]pyridin-2-yl)-phenylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Sodium hydrosulfide hydrate | HCID 16211346 | — |
| Reactant | 5-Methyl-2-(3-nitro-phenyl)-oxazolo[4,5-b]pyridine | HCID 59679906 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-(5-Methyl-oxazolo[4,5-b]pyridin-2-yl)-phenylamine | HCID 59679878 | 45.3% |
Reaction Steps
5-Methyl-2-(3-nitro-phenyl)-oxazolo[4,5-b]pyridine (50 mg, 0.196 mmol) was mixed with 6 mL of MeOH along with 2 mL of water and 66 mg of sodium hydrosulfide hydrate. The reaction mixture was stirred under reflux for 2 hours. It was then concentrated and extracted with CH2Cl2. The combined organic layers were dried (Na2SO4) and concentrated to afford 20 mg of 3-(5-methyl-oxazolo[4,5-b]pyridin-2-yl)-phenylamine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08088928B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-f10cd17fdb0e4018a6f3ed8c3081eb26 |
| Source note | uspto-grants-2012_01 |