HCID 57609712, compound → HCID 57609723, compound

Participants

Reaction Steps

Prepared according to the representative procedure (Method C) for preparation of keto-acid intermediate from benzyl ester 54e (0.320 mg, 0.866 mmol), palladium on carbon (35 mg) in a mixture of solvent THF (10 mL) afford keto acid 55e (250 mg, 99%) as a colorless oil. IR (neat) 1723, 1612 cm−1; 1H NMR (500 MHz, CDCl3) δ 7.13 (d, J=8.5 Hz, 2H), 6.90 (d, J=8.0 Hz, 2H), 4.51 (s, 2H), 4.05 (s, 2H), 3.81 (s, 3H), 3.68 (s, 2H), 2.30 (s, 3H) (only major peaks were assigned); LRMS (ESI) Calcd. for C14H17NO5 [M−H] 278, found 278; HRMS (ESI) Calcd. for C14H17NO5 [M−H] 278.1028, found 278.1025.

Provenance & Evidence