Diisopropylethylamine → HCID 57897211, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of 5-bromo-4-chloro-3-nitro-pyridin-2-ylamine (0.126 g, 0.50 mmol) and isopropanol (9 ml) was added 1-(4-fluorobenzyl)-1,4-diazepane×2HCl (0.155 g, 0.55 mmol) followed by diisopropylethylamine (0.30 ml, 1.70 mmol). The reaction mixture was heated at 45° C. for 24 h, then allowed to cool to room temperature. The precipitate was collected by filtration and washed with isopropanol and diethyl ether. The title compound was thus obtained as a yellow solid (0.110 g, 52%); 1H-NMR (500 MHz, DMSO-d6) 1.82 (m, 2H), 2.67 (m, 4H), 3.17 (m, 2H) and 3.24 (t, J=5.85 Hz, 2H) (homopiperazine protons), 3.61 (s, 2H, N—CH2), 6.95 (s, 2H, NH2), 7.15 (t, J=9.10 Hz, 2H) and 7.35 (dd, J=10.20, 3.60 Hz, 2H) (3,5-ArH and 2,6-ArH), 8.17 (s, 1H, 6-H);

Provenance & Evidence