Acetone → 5-[5-(4-Chloro-phenyl)-2-ethyl-thiophen-3-yl]-4-hydroxy-cyclopent-2-enone

Participants

Reaction Conditions

Reaction Steps

To a solution of [5-(4-chloro-phenyl)-2-ethyl-thiophen-3-yl]-furan-2-yl-methanol (2.52 g, 7.9 mmol) in acetone (30 ml) and water (5 ml) is added polyphosphoric acid (0.5 ml) and the resulting solution heated at 60° C. for 5 hours. The resulting black solution is concentrated in vacuo and purified by flash chromatography on silica gel to give 5-[5-(4-chloro-phenyl)-2-ethyl-thiophen-3-yl]-4-hydroxy-cyclopent-2-enone as a clear gum (320 mg)

Provenance & Evidence