反应详情

This was prepared using the same procedure as for 2-(4-(2-amino-5-bromo-3-nitropyridin-4-yl)piperazin-1-yl)-N-(thiazol-2-yl)acetamide, but here using 5-bromo-4-chloro-3-nitropyridin-2-amine (300 mg, 1.19 mmol), DIPEA (1.1 eq, 1.31 mmol, 0.23 mL), isopropanol (7 mL) and 1-ethylpiperazine (1.1 eq, 1.31 mmol, 0.17 mL). After 18 h the precipitate was filtered and washed with cold water (2×3 mL) to give the product (212 mg, 54%) as a yellow solid; 1H-NMR (500 MHz, DMSO-d6) 1.04 (t, J=7.0 Hz, 3H, CH2CH3), 2.46-2.58 (2 m, 6H, CH2CH3 and piperazine N(CH2)2), 3.08 (br s, 4H, piperazine N(CH2)2), 6.98 (br s, 2H, NH2), 8.16 (s, 1H, pyridine H-6);

1. customThis was prepared
2. filtrationAfter 18 h the precipitate was filtered
3. washwashed with cold water (2×3 mL)