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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 4169Generated: October 26, 2026

N-methylpropyn-2-ylamine → 5,11-Dihydro-11-[[N-methyl(2-propynyl)amino]carbonyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one

https://huagongshe.com/reaction/4169

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN-methylpropyn-2-ylamineHCID 96160—
Reactant11-chlorocarbonyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-oneHCID 11043962—
Product5,11-Dihydro-11-[[N-methyl(2-propynyl)amino]carbonyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-oneHCID 20152918—

Reaction Steps

Analogously to Example C, using 27.3 g (0.1 mol) of 11-chlorocarbonyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one and 7.0 g (0.1 mol) of N-methyl-propargylamine, 27 g (88% of theory) of the desired compound are obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04724236
Source datasetuspto-grants-1988_02
ORD IDord-40ce053f6f454522aede5b77a4a32553
Source noteuspto-grants-1988_02