Sodium Hydroxide → 4-[3-[6-(3-Bromo-5-methoxymethyl-phenoxy)-hexyl]-2-(2-carboxy-ethyl)-phenoxy]-butyric acid

Participants

Reaction Conditions

Reaction Steps

To a solution of 4-[3-[6-(3-Bromo-5-methoxymethyl-phenoxy)-hexyl]-2-(2-ethoxycarbonyl-ethyl)-phenoxy]-butyric acid ethyl ester (500 mg, 0.82 mmol) in hot ethanol (20 mL) was added aqueous 2.0 N sodium hydroxide (5 mL). The resulting solution was heated to 60° C. and stirred for 4 h. Then, the reaction mixture was cooled down and diluted with EtOAc, washed with 10% aq. HCl and brine. The combined ethyl acetate extracts were dried over anhydrous sodium sulfate and the solvent was removed under reduced pressure to afford 400 mg (89%) of title compound as a light yellow oil. HR-ES(+) calcd for C27H35O7Br [M+Na]+ 573.1458, observed 573.1459.

Provenance & Evidence