反应详情

A similar procedure as described in step 3, method B was used, starting from 4-[3-[6-(3-bromo-5-methoxymethyl-phenoxy)-hexyl]-2-(2-carboxy-ethyl)-phenoxy]-butyric acid (184 mg, 0.33 mmol), 3,4-difluorophenylboronic acid (106 mg, 0.66 mmol), [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II) (44 mg, 0.06 mmol), and cesium carbonate (434 mg, 1.33 mmol) to obtain 4-[2-(2-carboxy-ethyl)-3-[6-(3′,4′-difluoro-5-methoxymethyl-biphenyl-3-yloxy)-hexyl]-phenoxy]-butyric acid (180 mg, 93%) as a light yellow paste: ES(+)-HRMS m/e calcd for C33H38F2O7 (M+Na)+ 607.2478. found 607.2478.