反应详情

A similar procedure as described in step 3, method B was used, starting from 4-[3-[6-(3-bromo-5-methoxymethyl-phenoxy)-hexyl]-2-(2-carboxy-ethyl)-phenoxy]-butyric acid (209 mg, 0.38 mmol), 5-pyrimidinylboronic acid (94 mg, 0.76 mmol), [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II) (51 mg, 0.07 mmol), and cesium carbonate (492 mg, 1.51 mmol) to obtain 4-[2-(2-carboxy-ethyl)-3-[6-(3-methoxymethyl-5-pyrimidin-5-yl-phenoxy)-hexyl]-phenoxy]-butyric acid (146 mg, 70%) as a light brown paste: ES(+)-HRMS m/e calcd for C31H38N2O7 (M+H)+ 551.2752. found 551.2748.