反应详情

A similar procedure as described in step 3, method B was used, starting from 4-[3-[6-(3-bromo-5-methoxymethyl-phenoxy)-hexyl]-2-(2-carboxy-ethyl)-phenoxy]-butyric acid (175 mg, 0.31 mmol), 5-indoleboronic acid (104 mg, 0.64 mmol), [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II) (51 mg, 0.07 mmol), and cesium carbonate (417 mg, 1.28 mmol) to obtain 4-[2-(2-carboxy-ethyl)-3-{6-[3-(1H-indol-5-yl)-5-methoxymethyl-phenoxy]-hexyl}-phenoxy]-butyric acid (125 mg, 69%) as a light brown solid: ES(+)-HRMS m/e calcd for C35H41NO7 (M+Na)+ 610.2775. found 610.2774.