Iodoethane → 4-{2-(2-Ethoxycarbonyl-ethyl)-3-[6-(5-ethoxymethyl-4'-methanesulfonyl-biphenyl-3-yloxy)-hexyl]-phenoxy}-butyric acid ethyl ester

Participants

Reaction Steps

A similar procedure as described in Example 24, step 1 was used, starting from 4-{2-(2-ethoxycarbonyl-ethyl)-3-[6-(5-hydroxymethyl-4′-methanesulfonyl-biphenyl-3-yloxy)-hexyl]-phenoxy}-butyric acid ethyl ester (250 mg, 0.37 mmol), sodium hydride (29.9 mg, 0.75 mmol), and iodoethane (116.7 mg, 0.75 mmol) to obtain 4-{2-(2-ethoxycarbonyl-ethyl)-3-[6-(5-ethoxymethyl-4′-methanesulfonyl-biphenyl-3-yloxy)-hexyl]-phenoxy}-butyric acid ethyl ester (110 mg, 42%) as a light brown oil: ES(+)-HRMS m/e calcd for C39H52O9S (M+Na)+ 719.3224, found 719.3227.

Provenance & Evidence