HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 4-[2-(2-Carboxy-ethyl)-3-[6-(5-ethoxymethyl-4'-methanesulfonyl-biphenyl-3-yloxy)-hexyl]-phenoxy]-butyric acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 4-{2-(2-Ethoxycarbonyl-ethyl)-3-[6-(5-ethoxymethyl-4'-methanesulfonyl-biphenyl-3-yloxy)-hexyl]-phenoxy}-butyric acid ethyl ester | HCID 59496844 | — |
| Product | 4-[2-(2-Carboxy-ethyl)-3-[6-(5-ethoxymethyl-4'-methanesulfonyl-biphenyl-3-yloxy)-hexyl]-phenoxy]-butyric acid | HCID 46928390 | 97% |
Reaction Steps
A similar procedure as described in Example 24, step 2 was used, starting from 4-{2-(2-ethoxycarbonyl-ethyl)-3-[6-(5-ethoxymethyl-4′-methanesulfonyl-biphenyl-3-yloxy)-hexyl]-phenoxy}-butyric acid ethyl ester (101 mg, 0.145 mmol) and 1.0 N aqueous sodium hydroxide (1.5 mL) to afford 4-[2-(2-carboxy-ethyl)-3-[6-(5-ethoxymethyl-4′-methanesulfonyl-biphenyl-3-yloxy)-hexyl]-phenoxy]-butyric acid (90 mg, 97%) as a white solid: ES(+)-HRMS m/e calcd for C35H44O9S (M+Na)+ 663.2598. found 663.2594.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08088936B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-c1385899b42745bc9cf0da4662139891 |
| Source note | uspto-grants-2012_01 |