HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thiophene-3-boronic acid → 4-{2-(2-Carboxy-ethyl)-3-[6-(3-cyanomethyl-5-thiophen-3-yl-phenoxy)-hexyl]-phenoxy}-butyric acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thiophene-3-boronic acid | HCID 581760 | — |
| Reactant | 4-[3-[6-(3-Bromo-5-cyanomethyl-phenoxy)-hexyl]-2-(2-ethoxy carbonylethyl)-phenoxy]-butyric acid ethyl ester | HCID 59496834 | — |
| Product | 4-{2-(2-Carboxy-ethyl)-3-[6-(3-cyanomethyl-5-thiophen-3-yl-phenoxy)-hexyl]-phenoxy}-butyric acid | HCID 46928588 | — |
Reaction Steps
The title compound was prepared according to general method described in step 4 by reaction of 4-[3-[6-(3-cyanomethyl-5-bromo-phenoxy)-hexyl]-2-(2-ethoxycarbonyl-ethyl)-phenoxy]-butyric acid ethyl ester with thiophene-3-boronic acid. LC/MS indicated a purity of 100% as measured by UV 214 nM. Calculated for C31H36NO6S (M+H)1+ 550.22. found 550.20.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08088936B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-f1b9235a8aea4ba8a6f6bfef0cad5709 |
| Source note | uspto-grants-2012_01 |