HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium carbonate → HCID 59496813, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | (2,3-Dihydro-1,4-benzodioxin-6-yl)boronic acid | HCID 2776178 | — |
| Reactant | HCID 59496797 | HCID 59496797 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Product | HCID 59496813 | HCID 59496813 | 23% |
Reaction Steps
A similar procedure as described in Example 44, step 3 was used, starting from 4-[3-[6-(3-bromo-5-ethoxy-phenoxy)-hexyl]-2-(2-ethoxycarbonyl-ethyl)-phenoxy]-butyric acid ethyl ester (305 mg, 0.5 mmol), 1,4-benzodioxane-6-boronic acid (184 mg, 1.0 mmol), [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II) (55 mg, 0.075 mmol), and cesium carbonate (331 mg, 1.0 mmol) to obtain 4-[3-{6-[3-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-5-ethoxy-phenoxy]-hexyl}-2-(2-ethoxycarbonyl-ethyl)-phenoxy]-butyric acid ethyl ester (76 mg, 23%) as a colorless viscous oil: ES(+)-HRMS m/e calcd for C39H50O9 (M+Na)+ 685.3347. found 685.3353.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08088936B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-94689ca460e94d0e97fa978f6e47c3e7 |
| Source note | uspto-grants-2012_01 |