Sodium Hydroxide → HCID 46928779, compound

Participants

Reaction Steps

A similar procedure as described in Example 43, step 5 was used, starting from 4-[3-[6-(4′-chloro-5-ethoxy-biphenyl-3-yloxy)-hexyl]-2-(2-ethoxycarbonyl-ethyl)-phenoxy]-butyric acid ethyl ester (150 mg, 0.24 mmol) and 1.0 N aqueous sodium hydroxide (2.4 mL) to afford 4-[2-(2-carboxy-ethyl)-3-[6-(4′-chloro-5-ethoxy-biphenyl-3-yloxy)-hexyl]-phenoxy]-butyric acid (200 mg, 98%) as a light brown waxy solid: ES(+)-HRMS m/e calcd for C33H39ClO7 (M+Na)+ 605.2276. found 605.2278.

Provenance & Evidence