Sodium Hydroxide → HCID 46928780, compound

Participants

Reaction Steps

A similar procedure as described in Example 43, step 5 was used, starting from 4-[2-(2-ethoxycarbonyl-ethyl)-3-[6-(3′,4′-difluoro-5-ethoxy-biphenyl-3-yloxy)-hexyl]-phenoxy]-butyric acid ethyl ester (65 mg, 0.1 mmol) and 1.0 N aqueous sodium hydroxide (1.0 mL) to afford 4-[2-(2-carboxy-ethyl)-3-[6-(3′,4′-difluoro-5-ethoxy-biphenyl-3-yloxy)-hexyl]-phenoxy]-butyric acid (58 mg, 98%) as a light brown waxy solid: ES(+)-HRMS m/e calcd for C33H38F2O7 (M+Na)+ 607.2478. found 607.2481.

Provenance & Evidence