Sodium Hydroxide → HCID 46928889, compound

Participants

Reaction Steps

A similar procedure as described in Example 43, step 5 was used, starting from 4-[3-{6-[3-(2,2-difluoro-benzo[1,3]dioxol-5-yl)-5-ethoxy-phenoxy)-hexyl}-2-(2-ethoxycarbonyl-ethyl)-phenoxy]-butyric acid ethyl ester (395 mg, 0.58 mmol) and 1.0 N aqueous sodium hydroxide (5.8 mL) to afford 4-(2-(2-carboxy-ethyl)-3-{6-[3-(2,2-difluoro-benzo[1,3]dioxol-5-yl)-5-ethoxy-phenoxy]-hexyl}-phenoxy)-butyric acid (260 mg, 72%) as a light yellow solid: ES(+)-HRMS m/e calcd for C34H38F2O9 (M+Na)+ 651.2376. found 651.2381.

Provenance & Evidence