Cesium carbonate → HCID 59496803, compound

Participants

Reaction Steps

A similar procedure as described in Example 43, step 4 was used, starting from 4-[3-[6-(3-bromo-5-cyclopentylmethoxy-phenoxy)-hexyl]-2-(2-ethoxycarbonyl-ethyl)-phenoxy]-butyric acid ethyl ester (136 mg, 0.2 mmol), 3-thiophenylboronic acid (53 mg, 0.41 mmol), [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II) (73 mg, 0.1 mmol), and cesium carbonate (134 mg, 0.41 mmol) to obtain 4-[3-[6-(3-cyclopentylmethoxy-5-thiophen-3-yl-phenoxy)-hexyl]-2-(2-ethoxycarbonyl-ethyl)-phenoxy]-butyric acid ethyl ester (129 mg, 95%) as a colorless viscous oil: ES(+)-HRMS m/e calcd for C39H52O7S (M+Na)+ 687.3326. found 687.3328.

Provenance & Evidence