HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-[3-[6-(5-Acetyl-biphenyl-3-yloxy)-hexyl]-2-(2-ethoxycarbonyl-ethyl)-phenoxy]-butyric acid ethyl ester → 4-[3-[6-(5-Acetyl-biphenyl-3-yloxy)-hexyl]-2-(2-carboxy-ethyl)-phenoxy]-butyric acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-[3-[6-(5-Acetyl-biphenyl-3-yloxy)-hexyl]-2-(2-ethoxycarbonyl-ethyl)-phenoxy]-butyric acid ethyl ester | HCID 59496818 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Product | 4-[3-[6-(5-Acetyl-biphenyl-3-yloxy)-hexyl]-2-(2-carboxy-ethyl)-phenoxy]-butyric acid | HCID 46929081 | 66% |
Reaction Steps
A similar procedure as described in Example 4, step 5 was used, starting from 4-[3-[6-(5-acetyl-biphenyl-3-yloxy)-hexyl]-2-(2-ethoxycarbonyl-ethyl)-phenoxy]-butyric acid ethyl ester (282 mg, 0.47 mmol) and 1.0 N aqueous sodium hydroxide (10 mL) to afford 4-[3-[6-(5-acetyl-biphenyl-3-yloxy)-hexyl]-2-(2-carboxy-ethyl)-phenoxy]-butyric acid (168 mg, 66%) as a white solid: ES(+)-HRMS m/e calcd for C33H38O7 (M+Na)+ 569.2510. found 569.2508.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08088936B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-07e6156de68b419f887fb7c69239f0a6 |
| Source note | uspto-grants-2012_01 |