Cesium carbonate → HCID 59496823, compound

Participants

Reaction Conditions

Reaction Steps

Trifluoro-methanesulfonic acid 3-cyclopentanecarbonyl-5-trifluoromethanesulfonyloxy-phenyl ester (1.5 g) was dissolved in 1,2-dimethoxyethane (30 mL), followed by addition of cesium carbonate (1.5 g). The resulting suspension was stirred at 80° C. for 3 h and then quenched with saturated solution of ammonium chloride. The solution was then extracted with diethyl ether and combined etherate extracts were washed with brine and dried over anhydrous sodium sulfate. The filtrate was concentrated under reduced pressure and purified on a silica gel column using ethyl acetate and hexanes to yield 300 mg of the title compound (28% yield). HRMS calcd for C13H13O5S1F3 [M+H]+ 339.0509, observed 339.0509.

Provenance & Evidence