Water → HCID 46183722, compound

Participants

Reaction Conditions

Reaction Steps

To the solution of 0.22 g (0.4 mmol) 4-{2-[2-(4-chloro-phenyl)-5,6-difluoro-benzoimidazol-1-yl]-2-cyclohexyl-ethoxy}-benzoic acid ethyl ester in 3 mL dioxane, 50 mg (1.2 mmol) lithium hydroxide monohydrate and 3 mL water were added and the solution was stirred for 2 h at 100° C. After cooling to room temperature dioxane was evaporated and 7.6 mL 1N hydrochloric acid was added under stirring. The resulting suspension was filtered, thoroughly washed with water and the filter cake dried under high vacuum to give the product as a white solid (94%). MS (Turbo Spray): m/z=509.2 [M+H].

Provenance & Evidence