Hydrochloric Acid → HCID 46184941, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 0.18 g (0.32 mmol) (6-{2-[2-(4-chloro-phenyl)-5,6-difluoro-benzoimidazol-1-yl]-2-cyclohexyl-ethoxy}-pyridin-3-yloxy)-acetic acid ethyl ester in 2 mL tetrahydrofuran 2 mL water and 0.13 mL (0.77 mmol) 32% aqueous sodium hydroxide solution were added. The mixture was stirred at 75° C. for 1.5 h and then poured on 20 mL 1M aqueous hydrochloric acid. The aqueous layer was extracted three times with ethyl acetate. The combined organic layers were washed with water and brine, dried over magnesium sulfate and evaporated to dryness. The residue was suspended in a mixture of acetonitrile and water, filtered and washed with acetonitrile to give the desired product as a white solid (61%). MS (Turbo Spray): m/z=542.3 [M+H].

Provenance & Evidence